Saturday, December 31, 2011
Friday, December 30, 2011
Thursday, December 29, 2011
Monday, December 26, 2011
Thursday, December 22, 2011
The Photoshop Awards: Wonky McValtrex On Vanity Fair España.
The offices of Vanity Fair España must have been sucked into a time warp and shoved into the raw asshole of 2004 while they were doing their January issue, because why in SANTO DIOS fuckery hell would they put this vapid relic of skank trash on their cover? Parasite Hilton shouldn't have been on the cover in 2004, and she really shouldn't be on that shit now. Was nobody else available? Paz Vega's dog walker? Pedro Almodovar's nipple hair dandruff? The assistant to the royal groomer who prunes the ethereal dandelion bush on the Duchess of Alba's head? A homeless man who barfed on Javier Bardem's shoes once? Any of those should've been on the cover before this wax dildo in a weave. But you know, I'm not even sure that is Wonky. It could be an alien lizard wearing a mannequin's torn off face.
And do you blame that poor dog for wondering if there's enough coffee in that cup for it drown itself in? It's either that or face the doggy death closet of doom.
Wednesday, December 21, 2011
How the penis lost its spikes.
Sex would be a very different proposition for humans if — like some animals including chimpanzees, macaques and mice — men had penises studded with small, hard spines.
Now researchers at Stanford University in California have found a molecular mechanism for how the human penis could have evolved to be so distinctly spine-free. They have pinpointed it as the loss of a particular chunk of non-coding DNA that influences the expression of the androgen receptor gene involved in hormone signalling.
"It is a small but fascinating part of a bigger picture about the evolution of human-specific traits," said Gill Bejerano, a developmental biologist at Stanford who led the work along with colleague David Kingsley. "We add a molecular perspective to a discussion that has been going on for several decades at least."
Published in Nature today1, the research also suggests a molecular mechanism for how we evolved bigger brains than chimpanzees and lost the small sensory whiskers that the apes — who are amongst our closest relatives and with whom it has been estimated we share 96% of our DNA — have on their face.
Monogamous strategy
It has long been believed that humans evolved smooth penises as a result of adopting a more monogamous reproductive strategy than their early human ancestors. Those ancestors may have used penile spines to remove the sperm of competitors when they mated with females. However, exactly how this change came about is not known.
The researchers did not set out to study penile spines. Rather, they were looking for chunks of DNA that had been lost from the human genome but not the chimp genome, so they could then try to pinpoint what those chunks did.
The approach differs from that in most studies, explain Bejerano and Kingsley, in looking at what has been deleted from the human genome rather than what is present. "In the case of our study, had you started from the human genome, there would be nothing there to see," says Bejerano.
They first systematically identified 510 DNA sequences missing in humans and present in chimps, finding that those sequences were almost exclusively from the non-coding regions of the genome, between genes. They then homed in on two sequences whose absence in humans they thought might be interesting — one from near the androgen receptor (AR) gene and one from near a gene involved in tumour suppression (GADD45G).
nserting the chimpanzee sequences into mouse embryos revealed that the former sequence produced both the hard penile spines and sensory whiskers present in some animals. The latter sequence acted as a kind of brake on the growth of specific brain regions — with the removal of its function appearing to have paved the way for the evolution of the larger human brain.
"The goal of the project was to find molecular lesions [losses] that underlie human evolutionary traits, with the examples illustrating different aspects of the principle," says Kingsley.
"Until we looked at where the DNA was expressed, we had no idea which switch — if any — it would actually control," adds Bejerano.
Other molecular biologists praised the work for its clever approach and said it would open up new avenues of inquiry, particularly for those working on the evolution of the human brain.
"It is detective work and a great reminder that, in the course of evolution, information is both gained and lost," said Sean Carroll, an expert in animal genetics and evolution at the University of Wisconsin, Madison.
"As so often with very good ideas, it seems almost obvious in hindsight," said Svante Pääbo, who directs the genetics department of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and was part of the team that recently sequenced the Neanderthal genome. "Since two of the almost 500 deleted sequences they identified turn out to be interesting, I am sure that several other ones on their list will turn out to be interesting too," he added. The researchers are continuing to analyse the remaining 508 DNA sequences.
David Haussler, who studies the molecular evolution of the human genome at the University of California, Santa Cruz, added that our ancestors' loss of penile spines is our gain today."Couples everywhere can be thankful that this particular piece of DNA was ditched," he says.
Tuesday, December 20, 2011
Special Delivery of the Day.
Special Delivery of the Day: YouTuber goobie55 claims this surveillance video shows a FedEx driver “delivering” his new Samsung flat screen monitor by tossing it haphazardly over the fence into some bushes.
“The sad part is that I was home at the time with the front door wide open,” says goobie55. “All he would have had to do was ring the bell on the gate. Now I have to return my monitor since it is broken.”
The Daily What.
How cheese makes it to the Christmas dinner table
Sales of cheese in the UK are higher over the Christmas period than at any other time over the year.
Varieties such as blue Stilton, which is made in only a few dairies in Britain, remain particularly popular.
Jenny Hill visited a dairy in Melton Mowbray to investigate how cheese makes it to the Christmas dinner table.
Sunday, December 18, 2011
Hot Slut Of The Day.
Jyoti Amge, the world's new reigning shortest living woman! Contrary to popular belief, Ryan Seacrest did not hold the record for the world's shortest living woman, that title belonged to 22-year-old American Bridgette Jordan. But on Jyoti's 18th birthday yesterday, Guinness World Records measured her in at 24.7 inches tall and crowned her the new record holder. Jyoti is 3 inches shorter than Bridgette. Jyoti is a two foot tall petal of happiness plucked from a sunshine blossom and told reporters that she's grateful to be the size of Thumbelina's lady condom:
"I feel grateful to be this size. After all, if I weren't small and had not achieved these world records I might never have been able to visit Japan and Europe, and many other wonderful countries.
I'm straining so hard to keep from making a "she's almost the size of Tommy Lee's peen" joke that I think I've shrunk down to the size of the world's shortest gay.
Jyoti hopes to become a Bollywood star and let's hope all her dreams come true, because she deserves that shit. Jyoti seems all kinds of happy and not just because she can ride a pug like a horse and slow dance with a Prince Hot Ginge doll.
Friday, December 16, 2011
Thursday, December 15, 2011
Tuesday, December 13, 2011
Saturday, December 10, 2011
Hot Slut Of The Day!
The Grooming Owl! With Harry Potter being over, owls have to keep busy doing some kind of shit, so this one went into the extremely lucrative dog grooming business. Just look at that owl preening the shit out of that dog by picking off his fur fleas and combing at his hair. Or maybe that owl is picking at that dog's body to see which parts are most tender and delicious. Whatever the case may be, strange adorableness is what's happening here. Grooming that dog, adorable! Trying to eat that bitch until only bones are left, adorable!
Dlisted.
Friday, December 9, 2011
Thursday, December 8, 2011
Wednesday, December 7, 2011
Monday, December 5, 2011
ASHTON KUTCHER SPOTTED SANS WEDDING RING.
A wedding ring-less Ashton Kutcher tries to hide from the cameras as he leaves a Chevron gas station in West Hollywood. Kutcher and wife Demi Moore recently announced their split following rumors of Kutcher's infidelity.
Pacific Coast News On Line.
Pacific Coast News On Line.
Sunday, December 4, 2011
Saturday, December 3, 2011
Friday, December 2, 2011
Monday, November 28, 2011
Subscribe to:
Posts (Atom)